Keep an eye on Carefully (3)pentobarbital will reduce the extent or outcome of diazepam intranasal by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Check. Strong or moderate CYP3A4 inducers may well improve price of diazepam elimination; hence, efficacy of diazepam may be diminished.
pentobarbital will lessen the extent or effect of stiripentol by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Stay clear of or Use Alternate Drug. If unable to avoid coadministration of stiripentol with strong CYP3A4 inducers, enhance stiripentol dose.
Minimal (1)pentobarbital will reduce the extent or influence of paclitaxel protein sure by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Minor/Significance Not known.
Observe Intently (1)pentobarbital will reduce the level or impact of tofacitinib by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Keep an eye on. Loss of, or lowered reaction to tofacitinib may occur when coadministered with potent CYP3A4 inducers
pentobarbital will decrease the extent or outcome of losartan by affecting hepatic enzyme CYP2C9/10 metabolism. Slight/Importance Unfamiliar.
Barbiturates are pregnancy classification D medication and are revealed to cause fetal injury if used in pregnant sufferers. This class of medicine can cross the placental barrier and distribute through the entire fetal tissue with the very best concentrations while in the more info liver, brain, and placenta.
pentobarbital will decrease the level or impact of estropipate by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Check.
pentobarbital will lessen the level or outcome of paclitaxel by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Minor/Importance Unfamiliar.
pentobarbital will decrease the level or effect of etravirine by affecting hepatic enzyme CYP2C9/ten metabolism. Use Warning/Observe.
fentanyl intranasal and pentobarbital each enhance sedation. Stay clear of or Use Alternate Drug. Limit use to sufferers for whom alternate treatment possibilities are inadequate
pentobarbital will decrease the level or influence of alfentanil by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Minor/Significance Unfamiliar.
pentobarbital will decrease the extent or influence of levonorgestrel oral/ethinylestradiol/ferrous bisglycinate by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Keep track of Closely. The efficacy of hormonal contraceptives may very well be reduced.
To stay away from the large possible for morbidity and mortality associated with pentobarbital, the pharmacist should really propose prescribing clinicians safer different agents. Nurses ought to monitor the affected individual at subsequent visits, verifying medication compliance and treatment method success.
pentobarbital will minimize the extent or effect of almotriptan by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Watch.